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「Biophysics and Physicobiology」に Hisashi Shidara, Susumu Jitsuki, Kiwamu Takemoto による "Chromophore-assisted light inactivation of target proteins for singularity biology" をJ-STAGEの早期公開版として掲載

2024年02月15日 学会誌

日本生物物理学会欧文誌［Biophysics and Physicobiology］に以下の論文が早期公開されました。

Hisashi Shidara, Susumu Jitsuki, Kiwamu Takemoto
"Chromophore-assisted light inactivation of target proteins for singularity biology"

URL:https://doi.org/10.2142/biophysico.bppb-v21.s009


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Abstract
Singularity phenomena are rare events that occur only with a probability of one in tens of thousands and yet play an important role in the fate of the entire system. Recently, an ultra-wide-field microscopy imaging systems, AMATERAS, have been developed to reliably capture singularity phenomena. However, to determine whether a rare phenomenon captured by microscopy is a true singularity phenomenon—one with a significant impact on the entire system—, causal analysis is required. In this section, we introduce the CALI method, which uses light to inactivate molecules as one of the techniques enabling causal analysis. In addition, we discuss the technical innovations of the CALI method that are required to contribute to the future development of singularity biology.


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