ニュース

2018年08月22日 掲載 (Published 08/22/2018)


「Biophysics and Physicobiology」にHiroyuki Terashima et al. “Novel insight into an energy transduction mechanism of the bacterial flagellar type III protein export”を掲載

日本生物物理学会欧文誌[Biophysics and Physicobiology]に以下の論文が新規掲載されました。

Hiroyuki Terashima, Katsumi Imada “Novel insight into an energy transduction mechanism of the bacterial flagellar type III protein export”

【Significance】
Bacterial T3SS

Bacterial Type III secretion system (T3SS) is a protein translocator to deliver virulence factors or its own axial structure components. The molecular mechanism of protein export is still obscure due to difficulties in controlling measurement conditions in vivo. We developed an in vitro protein transport assay system using inverted membrane vesicles (IMVs). Our method reproduced protein export of the flagellar T3SS in IMV and the subsequent flagellar assembly. We demonstrated that T3SS can drive protein export by using either ATP-hydrolysis energy or proton motive force. Our method will give us novel insights into the functional mechanisms of T3SS.


Biophysics and Physicobiology, Vol.15, pp. 173-178

URL:https://www.jstage.jst.go.jp/article/biophysico/15/0/15_173/_article/