「Biophysics and Physicobiology」に Sakura Takada, Kei Fujiwara による "Artificial cell system as a tool for investigating pattern formation mechanisms of intracellular reaction-diffusion waves" をJ-STAGEの早期公開版として掲載
2024年10月10日 学会誌
日本生物物理学会欧文誌[Biophysics and Physicobiology]に以下の論文が早期公開されました。
Sakura Takada, Kei Fujiwara
"Artificial cell system as a tool for investigating pattern formation mechanisms of intracellular reaction-diffusion waves"
URL:https://doi.org/10.2142/biophysico.bppb-v21.0022
Large Image
- Abstract
- Intracellular positional information is crucial for the precise control of biological phenomena, including cell division, polarity, and motility. Intracellular reaction-diffusion (iRD) waves are responsible for regulating positional information within cells as morphogens in multicellular tissues. However, iRD waves are explained by the coupling of biochemical reactions and molecular diffusion which indicates nonlinear systems under far from equilibrium conditions. Because of this complexity, experiments using defined elements rather than living cells containing endogenous factors are necessary to elucidate their pattern formation mechanisms. In this review, we summarize the effectiveness of artificial cell systems for investigating iRD waves derived from their high controllability and ability to emulate cell-size space effects. We describe how artificial cell systems reveal the characteristics of iRD waves, including the mechanisms of wave generation, mode selection, and period regulation. Furthermore, we introduce remaining open questions and discuss future challenges even in Min waves and in applying artificial cell systems to various iRD waves.
URL:
https://doi.org/10.2142/biophysico.bppb-v21.0022