Biophysics and Physicobiology Editors' Choice Award

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Biophysics and Physicobiology Editors' Choice Award

日本生物物理学会では、前年にBiophysics and Physicobiology誌に掲載された論文(依頼論文は原則対象外)の中から、編集委員会による選考を経て、生物物理学に寄与するユニークな論文に対して、「Biophysics and Physicobiology Editors' Choice Award」を授与します。



Biophysics and Physicobiology Editors' Choice Award選考規定

第10回Biophysics and Physicobiology Editors' Choice Award受賞論文(2023)

“Quantitative and kinetic single-molecule analysis of DNA unwinding by Escherichia coli UvrD helicase”
Hiroaki Yokota
Biophysics and Physicobiology, Vol. 19, e190006 (2022)

【授賞理由】Editor-in-Charge : Ishijima, Akihiko

Two conflicting models of the functional unit of helicase, monomeric and dimeric, were validated using the author's single-molecule imaging technique.

“Phenotypic systems biology for organisms: Concepts, methods and case studies”
Takao K. Suzuki
Biophysics and Physicobiology, Vol. 19, e190011 (2022)

【授賞理由】Editor-in-Charge: Komatsuzaki, Tamiki

In biology, genotypes are one of the most crucial characteristics but this paper addresses design principles of phenotypes in organisms, which remains poorly understood, in contrast to understanding molecular mechanisms of living organisms.
This reviews a way of investigating phenotypic systems called phylogenetic comparative method that classifies the components in phenotype, and demonstrates the potentials by using wing patternsdisc of butter flies. This is one of very unique systems biology researches focusing on phenotypic differences, and should be awarded.

“Dorsolateral prefrontal cortex sensing analgesia”
Etsuro Ito, Kotaro Oka, Fusako Koshikawa
Biophysics and Physicobiology, Vol. 19, e190014 (2022)

【授賞理由】Editor-in-Charge: Kawato, Suguru

This review article is a unique and valuable paper.
Treatments of chronic pain have been difficult problems.
This paper describes that pyramidal thorn patche methods in the pain region have been effective on pain relief in patients. As one example, near-infrared spectroscopy revealed that the left side of dorsolateral prefrontal cortex is inactivated in patients experiencing pain relief during patch treatments.

“Coarse-grained molecular dynamics simulations of base-pair mismatch recognition protein MutS sliding along DNA”
Keisuke Inoue, Shoji Takada, Tsuyoshi Terakawa
Biophysics and Physicobiology, Vol. 19, e190015 (2022)

【授賞理由】Editor-in-Charge: Kitao, Akio

This paper reports coarse-grained simulations of conformation-dependent sliding of MutS protein on DNA. The authors reported the mechanisms of DNA mismatch search by MutS protein. They showed that diffusion of MutS along DNA was significantly dependent on the protein conformation. The results are consistent with experimental data, which also provides interesting insights into MutS motion on DNA. This is an interesting paper, and I would recommend it as suitable for the award.

“Epigenetic-structural changes in X chromosomes promote Xic pairing during early differentiation of mouse embryonic stem cells”
Tetsushi Komoto, Masashi Fujii, Akinori Awazu
Biophysics and Physicobiology, Vol. 19, e190018 (2022)

【授賞理由】Editor-in-Charge: Yoshikawa, Kenichi

The pairing event between the regions of X chromosome inactivation center (Xic) pairing has been attracting much interests, in relation to various important biological subjects, such as X chromosome inactivation, circadian clock, dynamics in structure & function of nucleus. The authors constructed course-grained 3D model based on the recently published experimental data with single-cell DNA replication profiling obtained through Hi-C measurements in addition to the map of GT contents. Where the data of ES cells and 2-day cells are available. The mathematical model constructed by the authors indicates that X-chromosomes exhibit the rearrangement of their distributions of open/closed chromatin regions during cell differentiation. The authors propose a new working hypothesis that the rearrangement of open/closed chromatin regions on X-chromosome surfaces promoted the mutual approach of the Xic pair. Frankly speaking, the present study is in a primitive stage toward the basic understanding of the mechanism in living cells. However, it should be stressed that such kind of numerical study would stimulate the scientists in related subjects to make clear the underlying mechanism of dynamic of self-organization in nucleus and in living cells.

“Structural overview of the translocase of the mitochondrial outer membrane complex”
Yuhei Araiso, Toshiya Endo
Biophysics and Physicobiology, Vol. 19, e190022 (2022)

【授賞理由】Editor-in-Charge: Oiki, Shigetoshi

This review by Araiso and Endo is a comprehensive and excellent, readily readable for the general readers of BPPB. The review summarizes the introductory story on mitochondrial protein transport to the current status of the translocase studies with the structural information, including those revealed by the authors. The discussion on the transport mechanism based on the structural information is intriguing. Future perspective is helpful for the general readers to overview the study of this field.
Accordingly, I recommend this review for the Editor's Choice Award.

Biophysics and Physicobiology編集委員会