「Biophysics and Physicobiology」に Tomoya Katakai, Taku Okazaki による "A battle between two biological singularities: Immune response vs. cancer" をJ-STAGEの早期公開版として掲載
2024年02月09日 学会誌
日本生物物理学会欧文誌[Biophysics and Physicobiology]に以下の論文が早期公開されました。
Tomoya Katakai, Taku Okazaki
"A battle between two biological singularities: Immune response vs. cancer"
URL:https://doi.org/10.2142/biophysico.bppb-v21.s006
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- Abstract
- In a post-growth multicellular organism, the phenomenon in which a small number of rare cells can be the starting point for inducing a dramatic change in the entire system is considered a “biological singularity.” The immune response and cancer can be regarded as singularity phenomena in mammals, but their nature is fundamentally different. The immune response is considered a “programmed” singularity, whereas cancer is an “unprogrammed” singularity. These two systems perpetually engage in a cycle of attack and defense within the organism. The outcome is depending on the wining system, which determines whether the individual experiences a state resembling light or darkness. However, the overall mechanism of the competition remains unclear and is expected to be elucidated with future innovations in bioimaging technologies. Immune checkpoint blockade therapy is a means by which the two singularity balances can be artificially manipulated; therefore, mechanistic insight is necessary for cancer treatment strategies. Altogether, these findings provide a different perspective crucial for understanding the behavior of dynamic cell populations in multicellular organisms.
URL:
https://doi.org/10.2142/biophysico.bppb-v21.s006