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「Biophysics and Physicobiology」に Rei Shirakawa, Yuto Kurata, Takaomi Sakai による "Regulation of long-term memory by a few clock neurons in Drosophila" をJ-STAGEの早期公開版として掲載

2024年01月24日 学会誌

日本生物物理学会欧文誌[Biophysics and Physicobiology]に以下の論文が早期公開されました。

Rei Shirakawa, Yuto Kurata, Takaomi Sakai
"Regulation of long-term memory by a few clock neurons in Drosophila"

URL:https://doi.org/10.2142/biophysico.bppb-v21.s002


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Abstract
Identification of the neural circuits in the brain regulating animal behavior and physiology is critical for understanding brain functions and is one of the most challenging goals in neuroscience research. The fruitfly Drosophila melanogaster has often been used to identify the neural circuits involved in the regulation of specific behaviors because of the many neurogenetic tools available to express target genes in particular neurons. Neurons controlling sexual behavior, feeding behavior, and circadian rhythms have been identified, and the number of neurons responsible for controlling these phenomena is small. The search for a few neurons controlling a specific behavior is an important first step to clarify the overall picture of the neural circuits regulating that behavior. We previously found that the clock gene period (per), which is essential for circadian rhythms in Drosophila, is also essential for long-term memory (LTM). We have also found that a very limited number of per-expressing clock neurons in the adult brain are required for the consolidation and maintenance of LTM. In this review, we focus on LTM in Drosophila, introduce the concept of LTM regulation by a few clock neurons that we have recently discovered, and discuss how a few clock neurons regulate Drosophila LTM.

URL: https://doi.org/10.2142/biophysico.bppb-v21.s002



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