「Biophysics and Physicobiology」に Keisuke Fujiyama, Tomoya Hino, Shingo Nagano による "Diverse reactions catalyzed by cytochrome P450 and biosynthesis of steroid hormone" を掲載

2022年06月21日 学会誌

日本生物物理学会欧文誌［Biophysics and Physicobiology］に以下の論文が公開されました。

Keisuke Fujiyama, Tomoya Hino, Shingo Nagano
"Diverse reactions catalyzed by cytochrome P450 and biosynthesis of steroid hormone"

【Significance】
Steroid hormones regulate the physiologies of animals, plants, and insects, and most steroid hormone biosynthetic pathways, excluding those in insects have been clarified. Numerous cytochrome P450s (CYPs) are involved in animal steroid hormone biosynthesis, and their structures and reaction mechanisms have been extensively studied. However, those of plants and insects are yet to be fully investigated. Recently, we determined CYP90B1 structures, a key enzyme in brassinosteroid (BR) biosynthesis, and clarified the stereo-selective hydroxylation mechanism. Therefore, this review summarizes the current research progress on the P450 structure and its reaction mechanism in animal and plant steroid biosynthesis.

Biophysics Physicobiology, 2022, Volume 19, Article ID: e190021



URL:https://doi.org/10.2142/biophysico.bppb-v19.0021

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