2022年04月14日 学会誌
日本生物物理学会欧文誌[Biophysics and Physicobiology]に以下の論文が公開されました。
Damien Simon, Atsushi Mukaiyama, Yoshihiko Furuike, Shuji Akiyama
"Slow and temperature-compensated autonomous disassembly of KaiB–KaiC complex"
【Significance】
In both prokaryotes and eukaryotes, circadian clock proteins are assembled and frozen into highly stable hetero-multimeric complexes at night, but they are disassembled autonomously at dawn to terminate internal biological night. In this study, we experimentally determined the time scale and temperature dependence of the autonomous disassembly of the KaiB–KaiC complex, one of the major clock-protein complexes in the cyanobacterial circadian clock system. Our results clearly demonstrate that the timing of KaiB release from KaiC and its temperature dependence are governed by the structure and physicochemical state of KaiC.
Biophysics Physicobiology, 2022, Volume 19 Article ID: e190008
URL: https://doi.org/10.2142/biophysico.bppb-v19.0008