「Biophysics and Physicobiology」に Katsumasa Irie による "The insights into calcium ion selectivity provided by ancestral prokaryotic ion channels" を掲載

2021年12月04日 学会誌

日本生物物理学会欧文誌［Biophysics and Physicobiology］に以下の論文が公開されました。

Katsumasa Irie
"The insights into calcium ion selectivity provided by ancestral prokaryotic ion channels"

【Significance】
Prokaryotic proteins play an important role in the structural biology. Voltage-dependent Ca²⁺ channels (Cavs) are indispensable for coupling action potentials with Ca²⁺ signaling. Cavs were also predicted to have a prokaryotic counterpart; however, it has not been identified, yet. The homotetrameric channel obtained from Meiothermus ruber generates the calcium ion specific current. This channel belongs to a different cluster of phylogenetic trees than canonical prokaryotic channels. The glycine residue of its selectivity filter is a determinant for Ca²⁺ selectivity. This glycine residue is well conserved among eukaryotic Cavs, suggesting that there is a universal mechanism for Ca²⁺ selectivity.

Biophysics Physicobiology, 2021, Volume 18, Pages 274-283



URL:https://doi.org/10.2142/biophysico.bppb-v18.033

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