2021年02月05日 学会誌
日本生物物理学会欧文誌[Biophysics and Physicobiology]に以下の論文が公開されました。
Ryo Yoshizawa, Nobuhisa Umeki, Akihiro Yamamoto, Masayuki Murata, Yasushi Sako
"Biphasic spatiotemporal regulation of GRB2 dynamics by p52SHC for transient RAS activation"
【Significance】
The temporal regulation of cell signaling pathways is emerging as an indispensable process for normal cell activity but many of the underlying mechanisms remain unknown. We report in our current study that an apparently redundant pathway, RTK-SHC-GRB2, operates in parallel to the direct RTK-GRB2 pathway to regulate the dynamics of the GRB2 signaling activation of RAS, which is a key mechanism for cell fate changes. Our present results suggest that SHC changes the intracellular location of its major functions over time to enable the positive and negative regulation of GRB2 function and thereby realize the transient activation of RAS.
Biophysics Physicobiology, 2021, Volume 18, Pages 1-12
URL: https://doi.org/10.2142/biophysico.bppb-v18.001