2016年11月22日 学会誌
日本生物物理学会欧文誌[Biophysics and Physicobiology]に以下の論文が新規掲載されました。
Hiroshi Wako, Haruo Abe
“Characterization of protein folding by a Φ-value calculation with a statistical-mechanical model”
【Significance】
Protein folding characterized through a theoretical calculation of Φ values
The Φ values were calculated for 27 proteins with a simple statistical-mechanical model of protein folding. We considered that the correlation between the calculated and experimentally observed Φ values should illuminate the protein-folding mechanism active for each protein, such as the framework model or the nucleation-condensation model. In addition, we investigated other properties associated with protein folding such as the free-energy profile, contact-order profile, and sensitivity to the parameters used in the Φ-value calculation of each protein. Through such analyses, we tried to characterize protein folding from various perspectives to derive a unified theory of protein folding.
Biophysics and Physicobiology, Vol.13, pp. 263-279
URL: https://www.jstage.jst.go.jp/article/biophysico/13/0/13_263/_article