ニュース

「Biophysics and Physicobiology」に 〈Special Issue: "Protein-Ligand Interactions"〉 Nobuyuki Uchikoga et al. “Specificity of broad protein interaction surfaces for proteins with multiple binding partners”を掲載

2016年07月15日 学会誌

日本生物物理学会欧文誌[Biophysics and Physicobiology]に以下の論文が新規掲載されました。

Nobuyuki Uchikoga, Yuri Matsuzaki, Masahito Ohue, Yutaka Akiyama
“Specificity of broad protein interaction surfaces for proteins with multiple binding partners”

【Significance】
Specificity of broad protein interaction surfaces for proteins with multiple binding partners

Three proteins interacting with multiple ligand proteins (true partners) were analyzed to determine the specificity of interaction surfaces among true partners. Then, to observe interaction surfaces, broad interaction profiles (BIPs) were defined as the sum of interaction profiles of decoys, generated by the rigid-body docking process. Two types of BIPs were introduced; one was involved in amino acid sequences as its elements (BIP-seq), and the other was composed of interacting amino acid pairs (BIP-AAs). Notably, the specificity of BIP-AAs for true ligand proteins was higher than that of BIP-seqs.


Biophysics and Physicobiology, Vol.13, pp. 105-115

URL: https://www.jstage.jst.go.jp/article/biophysico/13/0/13_105/_article



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