お茶の水女子大学生命情報学教育研究センター
第24回「バイオインフォマティクスへの招待」セミナーのご案内

2010年05月25日 会合

日時：
　 平成22年6月3日（木）16時45分～
場所：
　お茶の水女子大学理学部2号館4階405号室
講演者：
　Prof. Sun-Shin Cha （Marine Biotechnology Research Center, Korea Ocean
　Research & Development Institute, South Korea）
演題：
　Structural and biochemical investigation of human DJ-1, a protein
　associated with the pathogenesis of Parkinson''s disease
要旨：
　 Human DJ-1 is a representative member of the DJ-1 superfamily whose
　members are evolutionarily distributed from Archaea to Eukarya.
　Mutations in the DJ-1 gene have been implicated in the autosomal
　recessive early-onset parkinsonism. DJ-1 is a soluble dimeric protein
　playing critical roles in response to oxidative stresses and neuronal
　maintenance. However, several lines of evidence point to the existence
　of nonfunctional aggregated form of DJ-1 in the brain of patients with
　some neurodegenerative diseases. Here, we show that inorganic phosphate
　(Pi), an important anion whose level was reported to be elevated in
　patients with Parkinson’s disease (PD) transforms DJ-1 into filamentous
　aggregates. According to the 2.4 angstrom crystal structure, DJ-1 dimers are
　linearly stacked through Pi-mediated interactions to form
　protofilaments, which are then bundled into a filamentous assembly. The
　Pi-induced aggregation of DJ-1 sensitizes cells to oxidative stress
　known to contribute to neuronal degeneration, suggesting the implication
　of DJ-1 aggregation in disease pathogenesis. Our study presented here
　opens new avenue to the elucidation of the implication of DJ-1 in the
　pathogenesis of neurodegenerative diseases including PD and to the
　development of inhibitors preventing DJ-1 aggregation.

参加費：無料（申し込み不要）
アクセス：丸ノ内線茗荷谷駅または有楽町線護国寺駅下車徒歩8分

主催：お茶の水女子大学生命情報学教育研究センター
　　　文部科学省ターゲットタンパク研究プログラム

問い合わせ先：
　　お茶の水女子大学生命情報学教育研究センター、

URL: yura.kei@ocha.ac.jp