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A low-cost electric micromanipulator and its application to single-cell electroporation
(Kazuma Shimizu, Norihiko Nishimura, Manato Oku, Chika Okimura, Yoshiaki Iwadate, Biophysics and Physicobiology 22, e220010 (2025), DOI: 10.2142/biophysico.bppb-v22.0010)
A low-cost electric micromanipulator consisting of three commercially available stages, three linear DC motors to drive them, and a lab-made control circuit, was assembled using a method that anyone can easily perform. This could make it easier, both economically and technically, to add micromanipulators to all of a laboratory’s microscopes. The device can be used for cutting a cell collective sheet by manipulation of a glass microneedle, for micropipette aspiration of a single adherent cell, and single-cell electroporation in a cell collective by gentle contact of an electroporation pipette tip with the cell surface.