"Current advances in the development of bioluminescent probes toward spatiotemporal trans-scale imaging" by Akihiro Sakama, Mariko Orioka, Yuki Hiruta is published in BPPB as the J-STAGE Advance Publication.
2024 February 02 BPPB
A following article is published as the J-STAGE Advance Publication in "Biophysics and Physicobiology".
Akihiro Sakama, Mariko Orioka, Yuki Hiruta
"Current advances in the development of bioluminescent probes toward spatiotemporal trans-scale imaging"
URL:https://doi.org/10.2142/biophysico.bppb-v21.s004
- Abstract
- Bioluminescence imaging has recently attracted great attention as a highly sensitive and non-invasive analytical method. However, weak signal and low chemical stability of the luciferin are conventional drawbacks of bioluminescence imaging. In this review article, we describe the recent progress on the development and applications of bioluminescent probes for overcoming the aforementioned limitations, thereby enabling spatiotemporal trans-scale imaging. The detailed molecular design for manipulation of their luminescent properties and functions enabled a variety of applications, including in vivo deep tissue imaging, long-term imaging, and chemical sensor.
