「Biophysics and Physicobiology」にLihsin Lee “Bohr equation and the lost allosteric Bohr effects in symmetry”を掲載

2019 December 23 BPPB

日本生物物理学会欧文誌[Biophysics and Physicobiology]に以下の論文が新規掲載されました。

Lihsin Lee “Bohr equation and the lost allosteric Bohr effects in symmetry”

A quantitative Bohr equation resides in the orthosteric and descriptive Hill equation

The cooperative hemoglobin is the crowning model of the versatile allosteric enzymes. The failure to model the cooperativity quantitatively since 1904 means the inevitable failures of both the allosteric quest of drugs and the discovery of the allosteric mechanism of disease. The application of the biophysical law of symmetry solved the centennial paradox incurred by the orthosteric Hill coefficient. Hemoglobin turns out to be nonorthosteric and then transforms itself from a descriptive Hill equation into a quantitative Bohr equation. The Monod-Wyman-Changeux (MWC) model erased the allosteric Bohr effects in the misused Hill equation with the prejudiced perceptiveness of cooperative oxygen binding.

Biophysics and Physicobiology, Vol.16, 490-503


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