「Biophysics and Physicobiology」にSarbani Chattopadhyaya et al. “A collective motion description of tubulin βT7 loop dynamics”を掲載

2019 November 29 BPPB

日本生物物理学会欧文誌[Biophysics and Physicobiology]に以下の論文が新規掲載されました。

Sarbani Chattopadhyaya, Debamitra Chakravorty, Gautam Basu “A collective motion description of tubulin βT7 loop dynamics”

Tubulin loop dynamics

Tubulin, an essential eukaryotic protein that plays an important role in cell division, is a target for anti cancer drugs. The binding of the anti-mitotic drug colchicine to tubulin is modulated by the conformational flip of a loop that also controls the polymerization of tubulin into microtubule. Flipped and un-flipped conformations of the loop are known but a detailed dynamic picture of the transition is poorly understood. Here we describe the flip by a reaction coordinate defined by two collective vectors—one captures the core flip and the other depicts the trigger to the flip.

Biophysics and Physicobiology, Vol.16, 264-273


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