「BIOPHYSICS」に〈Special Issue〉"TRP channels: their functional roles in medical sciences"を掲載

2015 February 13 BPPB


〈Special Issue〉"TRP channels: their functional roles in medical sciences"


Etsuro Ito
Preface of Special Issue “TRP channels: their functional roles in medical sciences”

BIOPHYSICS, Vol.11, pp. 7-8


Yi-Wen Lin, Chih-Cheng Chen
"IB4-negative TRPV1-expressing muscle afferent DRG neurons"

Muscle pain is closely related to acidosis and activation of proton-sensing ion channels. Accumulating evidence has shown that TRPV1 is involved in the development of chronic muscle pain associated with tissue acidosis. However, little is known about the involvement of TRPV1 in acid-induced depolarization in muscle nociceptors. Here we used the whole-cell patch clamp recording to characterize the electrophysiological properties in different subsets of TRPV1-expressing muscle nociceptors. We have identified two TRPV1-expressing neuron subtypes with distinguishable biophysical properties and discussed their possible roles in different types of muscle pain and in the transition from acute to chronic muscle pain.

BIOPHYSICS, Vol.11, pp. 9-16


Ji-Chen Ho, Chih-Hung Lee
"TRP channels in skin"

TRP channels are expressed in various non-neuronal cells in skin, including keratinocytes and melanocytes. They play important roles in various physiological and pathological functions, such as epidermal proliferation and differentiation, skin barrier regeneration, and dermal immune responses. In human diseases with perturbed epidermal differentiation, including skin cancers and inflammatory skin diseases, the expression of TRP channels is dysregulated. Thus, TRP channels might be good therapeutic targets in these diseases.

BIOPHYSICS, Vol.11, pp. 17-24


Wen-Li Hsu, Tohru Yoshioka
”Induction of Hsp by TRP channels in the heated skin”

Unexpectedly, there is no paper which discusses the relationships between TRP channels and heat shock proteins (Hsp), although both of them are highly connected each other in response to thermal matters in living cells. Thus we try to elucidate relationships between them, and reached the conclusion that Hsp production signals may be triggered by activation of TRP channels via elevation of intracellular calcium concentration, which is associated with production of reactive oxygen species by mitochondria. This hypothesis must be proved by the experiments using normal cells but not cancer cells, because the expression of these two proteins in cancer cells are quite different from those in normal cells.

BIOPHYSICS, Vol.11, pp. 25-32


Etsuro Ito, Yusuke Ikemoto, Tohru Yoshioka
”High Q10 of thermo-TRP channels”


Thermo-TRP channels are activated by distinct physiological temperatures, and are characterized by their unusually high temperature sensitivity (Q10). This high Q10 of thermo-TRP channels requires both large enthalpy and large entropy values, indicating that the activation process of the thermo-TRP channels resembles an unfolding process of globular proteins. The structure of the water surrounding thermo-TRP channels is also expected to change in response to the change in the structure of thermo-TRP channels. These thermodynamic issues are discussed in this note.

BIOPHYSICS, Vol.11, pp. 33-38

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