An article with the title "Multistep growth of amyloid intermediates and its inhibition toward exploring therapeutic way: A case study using insulin B chain and fibrinogen" by Naoki Yamamoto, Eri Chatani is published.
2022 June 01 BPPB
A following article is published in "Biophysics and Physicobiology".
Naoki Yamamoto, Eri Chatani
"Multistep growth of amyloid intermediates and its inhibition toward exploring therapeutic way: A case study using insulin B chain and fibrinogen"
【Significance】
Understanding molecular mechanisms about how prefibrillar intermediates, which accumulate prior to the amyloid fibril formation, convert to amyloid fibril is crucial for exploring therapeutic ways against amyloid-related diseases. We have developed a model system suitable for this purpose using an insulin-derived amyloid-prone peptide and fibrinogen as an amyloid inhibitor, in which it was shown that preventing the structural development of prefibrillar intermediate is crucial for the inhibition of fibril formation.
Biophysics Physicobiology, 2022, Volume 19, Article ID: e190017
URL:https://doi.org/10.2142/biophysico.bppb-v19.0017
