An article with the title "Epigenetic-structural changes in X chromosomes promote Xic pairing during early differentiation of mouse embryonic stem cells" by Tetsushi Komoto, Masashi Fujii, Akinori Awazu is published.
2022 June 01 BPPB
A following article is published in "Biophysics and Physicobiology".
Tetsushi Komoto, Masashi Fujii, Akinori Awazu
"Epigenetic-structural changes in X chromosomes promote Xic pairing during early differentiation of mouse embryonic stem cells"
【Significance】
Since the discovery of X chromosome inactivation center (Xic) pairing during cell differentiation of mouse embryonic stem cells, their physiological roles have been variously suggested. However, the driving force promoting such a dynamical process in crowded nuclei was not elucidated. The present study developed mathematical models of chromosomes in ES cells and early-differentiated cells based on their structural and epigenomic features. The experimental data analysis showed the drastic change in the distributions of open and closed chromatin regions on the X-chromosome during cell differentiation. The simulations of these models suggested such epigenomic changes promoted Xic pairing.
Biophysics Physicobiology, 2022, Volume 19, Article ID: e190018
URL:https://doi.org/10.2142/biophysico.bppb-v19.0018
