An article with the title "Molecular dynamics simulations of amyloid-β peptides in heterogeneous environments" by Yuhei Tachi, Satoru G. Itoh, Hisashi Okumura is published.
2022 April 20 BPPB
A following article is published in "Biophysics and Physicobiology".
Yuhei Tachi, Satoru G. Itoh, Hisashi Okumura
"Molecular dynamics simulations of amyloid-β peptides in heterogeneous environments"
【Significance】
The aggregates of amyloid-β (Aβ) peptides are considered the cause of Alzheimer’s disease. Aβ aggregation is accelerated at hydrophilic/hydrophobic interfaces such as the air–water interface and the neuronal cell membrane surface. Therefore, understanding the mechanism of the Aβ aggregation in such heterogeneous environments is significant for developing therapeutic agents and preventive drugs. In this review, we survey several studies that have elucidated the mechanism of the Aβ aggregation at the interfaces at the atomic level by molecular dynamics simulations.
Biophysics Physicobiology, 2022, Volume 19, Article ID: e190010
URL:https://doi.org/10.2142/biophysico.bppb-v19.0010
