An article with the title "Slow and temperature-compensated autonomous disassembly of KaiB–KaiC complex" by Damien Simon, Atsushi Mukaiyama, Yoshihiko Furuike, Shuji Akiyama is published.
2022 April 14 BPPB
A following article is published in "Biophysics and Physicobiology".
Damien Simon, Atsushi Mukaiyama, Yoshihiko Furuike, Shuji Akiyama
"Slow and temperature-compensated autonomous disassembly of KaiB–KaiC complex"
【Significance】
In both prokaryotes and eukaryotes, circadian clock proteins are assembled and frozen into highly stable hetero-multimeric complexes at night, but they are disassembled autonomously at dawn to terminate internal biological night. In this study, we experimentally determined the time scale and temperature dependence of the autonomous disassembly of the KaiB–KaiC complex, one of the major clock-protein complexes in the cyanobacterial circadian clock system. Our results clearly demonstrate that the timing of KaiB release from KaiC and its temperature dependence are governed by the structure and physicochemical state of KaiC.
Biophysics Physicobiology, 2022, Volume 19 Article ID: e190008
URL:https://doi.org/10.2142/biophysico.bppb-v19.0008
