「Biophysics and Physicobiology」にAkihiko Nakamura et al. “Crystalline chitin hydrolase is a burnt-bridge Brownian motor”を掲載

2020 June 10 BPPB

日本生物物理学会欧文誌[Biophysics and Physicobiology]に以下の論文が早期公開されました。

Akihiko Nakamura, Okazaki Kei-ichi, Tadaomi Furuta, Minoru Sakurai, Jun Ando and Ryota Iino “Crystalline chitin hydrolase is a burnt-bridge Brownian motor”

Revealing the moving mechanism of a burnt-bridge Brownian motor

Molecular motors need ATP or a chemical potential as the bias of moving direction. The major moving mechanisms are “power stroke” and “Brownian ratchet”, and these two mechanisms are mixed in many cases. In this study, we revealed that a chitin hydrolase is a pure “burnt-bridge” Brownian ratchet motor, which creates a forward bias by shortening of the rail and inhibition of the backward movement. From the viewpoint of application, chitin is the second most abundant biomaterial on the Earth. Therefore, revealing the chitin degradation mechanism of chitinase is helpful to improve the utilization of chitin.


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