「Biophysics and Physicobiology」にSouhei Sakata et al. “Domain-to-domain coupling in voltage-sensing phosphatase”を掲載

2017 June 23 BPPB

日本生物物理学会欧文誌[Biophysics and Physicobiology]に以下の論文が新規掲載されました。

Souhei Sakata, Makoto Matsuda, Akira Kawanabe and Yasushi Okamura “Domain-to-domain coupling in voltage-sensing phosphatase”

Coupling mechanisms in voltage-sensing phosphatase: common principle shared by voltage-gated ion channels?

Neuron, muscle cell, endocrine cell and sperm utilize signals of membrane potential. Such signals depend on activities of diverse types of voltage-gated ion channels. Voltage-gated ion channels share common structures: voltage sensor domain and pore-gate domain. Voltage-sensing phosphatase (VSP) does not contain pore-gate domain but instead the cytoplasmic enzyme region. The enzyme consists of the phosphatase domain and C2 domain and dephosphorylate phosphoinositides, like tumor suppressor phosphatase, PTEN. Conformational change of voltage sensor domain induces structural change of the enzyme. Recent studies have revealed details of relationships between voltage sensor domain and enzyme in VSP.

Biophysics and Physicobiology, Vol.14, pp.85-97


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