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Failed cytokinesis in AmiA:myosin II double KO cells.

Species name: Dictyostelium discoideum

National Institute of Advanced Industrial Science and Technology Taro Uyeda

The cellular slime mold Dictyostelium discoideum has two cell-cycle coupled methods of cytokinesis: contractile ring-dependent cytokinesis A and traction-mediated cytokinesis B. Mutant cells lacking mhcA, necessary for cytokinesis A, and AmiA, necessary for cytokinesis B, cannot perform both, and fail to divide following nuclear division (circled), forming binucleate cells. These cells express GFP-histone to visualize nuclear division.

Genetic and morphological evidence for two parallel pathways of cell cycle-coupled cytokinesis in Dictyostelium. J. Cell Sci., 115: 2241-2251.
Variations on a Theme - the Many Modes of Cytokinesis. Curr. Opin. Cell Biol., 16:55-60

(2013.08.23)

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