Department of Physics and Bio-AFM Frontier Research Center, Kanazawa University Toshio Ando, Takayuki Uchihashi, and Noriyuki Kodera
Myosin V is a double-headed motor protein involved in trafficking of vesicles in the cell. Hand-over-hand movement of a myosin V–HMM (tail-truncated myosin V) in 1 µM ATP was directly visualized by high-speed AFM at 7 frames per second. Scan range, 150 × 75 nm2 with 80 × 40 pixel. Foot stomp events occurred at the leading head are marked with light-blue triangles.
Annual Review of Biophysics 42: 393-414 (2013)
Nature 468: 72-76 (2010)
(2014.08.29)