第3回Biophysics and Physicobiology Editors' Choice Award

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  • 第3回Biophysics and Physicobiology Editors' Choice Award

日本生物物理学会では、前年に欧文誌Biophysics and Physicobiology誌に掲載された論文(依頼論文は原則対象外)の中から、編集委員会による選考を経て、生物物理学に寄与するユニークな論文に対して、「Biophysics and Physicobiology Editors' Choice Award」を授与します。
下記の通り受賞論文が決定いたしましたので、ここにお知らせします。

"Electrophysiological characteristics of IB4-negative TRPV1-expressing muscle afferent DRG neurons"
Yi-Wen Lin, Chih-Cheng Chen
BIOPHYSICS, Vol. 11, pp. 9-16 (2015)

【授賞理由】
In the present study, the authors showed that TRPV1-expressing neurons of dorsal root ganglia can be divided into two groups because of their distinguishable characteristics in various biophysical properties. These different biophysical properties are thought to annotate their different roles in chronic muscle pain. Thus, the present study comes into contact with the clarification of pain, and it is judged to be an outstanding research.

" Lever arm extension of myosin VI is unnecessary for the adjacent binding state"
Keigo Ikezaki, Tomotaka Komori, Yoshiyuki Arai, Toshio Yanagida
BIOPHYSICS, Vol. 11, pp. 47-53 (2015)

【授賞理由】
This paper aimed to determine how myosin VI moves by large, small forward steps and a backward step, and then takes adjacent binding state during movement on the actin filament. The authors made myosin VI/V chimera to replace the lever arm of myosin VI with IQ domains (stiff-arm) of myosin V to exclude the folding of lever arm extension. The chimera myosin construct showed the same stepping motion as myosin VI did. This observation supports the parallel lever arm model that the authors have proposed previously. The adjacent binding state is important for myosin VI to function as an anchor on the actin filament against a large external force. Their paper is on high level and the finding is worth receiving the Editor's Choice Award.

" Specific interactions between alkali metal cations and the KcsA channel studied using ATR-FTIR spectroscopy"
Yuji Furutani, Hirofumi Shimizu, Yusuke Asai, Shigetoshi Oiki, Hideki Kandori
Biophysics and Physicobiology, Vol. 12, pp. 37-45 (2015)

【授賞理由】
本論文において著者らは,KcsAチャネルとアルカリ金属イオンとの特異的相互作用に関し,ATR-FTIRの詳細なスペクトル追跡によって,蛋白質-イオンのミクロな相互作用変化を直接観測し,構造との綿密な議論によってイオン選択フィルタ機構への重要な知見を得た.研究対象の重要性,開発手法の緻密さ,得られた結果の重要性から,Editors' Choice Awardに値する優秀な研究と考え推薦をいたします.

" Structures of the Troponin Core Domain Containing the Cardiomyopathy-Causing Mutants Studied by Small-Angle X-ray Scattering"
Tatsuhito Matsuo, Soichi Takeda, Toshiro Oda, Satoru Fujiwara
Biophysics and Physicobiology, Vol. 12, pp. 145-158 (2015)

【授賞理由】
The paper describes a very interesting and thorough study of the effect of mutations on the structure of the troponin (Tn) complex in solution by small-angle X-ray scattering with a new modeling approach. These studies are important, because they should provide insights into signal propagation from calcium binding to tropomyosin via the complex by examining the effects of cardiomyopathy-causing mutants.

受賞者には、第54回年会の懇親会(11月26日(土)、ホテルグランド東雲)にて、賞状と記念品を授与いたします。

2016年7月
Biophysics and Physicobiology編集委員会