Title
Molecular Basis of ATP Energy

Organizers
Shun-ichi Kidokoro (Nagaoka University of Technology), Minoru Sakurai (Tokyo Institute of Technology)

Synopsis
ATP (adenosine triphosphate) is the energy source common to the lives on the earth; it has so-called "high-energy phosphate bonds" and the hydrolysis free energy drives many kinds of biological reactions. However, the molecular mechanism producing the free energy is not elucidated yet and the hydration effect on the energy especially atracts strong scientific interest. In this symposium, the historical background about this issue will be reviewed and the recent studies to understand the molecular basis of the ATP energy with the methods of spectroscopy, calorimetry, X-ray/neutron diffraction, quantum chemical calculation, and computer simulation will be presented and discussed.

Speakers
・ Takao Kodama (Osaka University): A Historical Overview of the Development of "ATP Eenergy" Concept
・ Makoto Suzuki (Tohoku University): Dynamic Properties of Water Hydrating ATP
・ Shun-ichi Kidokoro (Ngaoka University of Technology): Calorimetric Evaluation of ATP Hydrolysis
・ Nobuo Niimura (Ibaraki University): The Hydration Structure of ATP Binding Proteins
・ Takeshi Yamamoto (Kyoto University): Theoretical Study on the Reaction Pathway and Free Energy of ATP Hydrolysis in Solution
・ Nobuyuki Matsubayashi (Kyoto University): Free-Energy Analysis of Hydration Effect on Functional Molecules and Ions







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