Title
Bridging Single Molecule Biophysics and System Biology: New Experimental and Theoretical Challenges

Organizers
Kiyoto Kamagata (Tohoku University), Chun Biu Li (Hokkaido University)

Synopsis
 The rapid developments of single-molecule (SM) measurements and analysis methods in the past decade have revealed not only the detailed dynamics of biomolecules related to their functions, but also the real-time movements of biomolecules inside the cell. Despite the recent successes, it remains a big challenge in SM experiment and theory to establish a comprehensive connection between the structure and the dynamics of a single biomolecule, and to further understand the system-level properties of biophysical systems - how system of biomolecules perform function cooperatively. It is expected that the next generation of SM techniques including the high resolution multi-parameter SM measurements and multi-molecule measurements inside the cell will be crucial to shed new lights into these intriguing subjects.
 Instead of a meeting to report existing results, this symposium aims to bring together both experimental and theoretical experts from interdisciplinary fields, such as imaging, spectroscopy, microscopy, time series analysis, etc., to explore the future direction and perspectives in SM experiments; to discuss experimental and theoretical challenges and their possible solutions; and to inspire new collaborations that can lead to new line of researches in the field of SM biophysics.


Speakers
・Kiyoto Kamagata (Tohoku University): Long-time observation of a single molecule trapped in a capillary cell: application for protein folding
・Gopich Irina (NIH): Theory of single-molecule photon trajectories and FRET efficiency histograms
・ Yuji C Sasaki (The University of Tokyo): Internal Molecular Motions in Single Membrane Proteins seen from X-rays and Electrons
・Tomoko Masaike (Gakushuin University): Imaging of rotary molecular motor F1-ATPase
・Hideki Taguchi (The University of Tokyo)
・Yuichi Taniguchi (Harvard University): Quantifying the Escherichia coli proteome and transcriptome in a single cell with single-molecule sensitivity
・Li, Chun Biu (Hokkaido University): When one plus one is more than two: Theoretical challenges in learning from the next generation single- and multiple-molecule experiments









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