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An article with the title "Information quantity for secondary structure propensities of protein subsequences in the Protein Data Bank" by Ryohei Kondo, Kota Kasahara, Takuya Takahashi is published.

2022 February 22 BPPB

A following article is published in "Biophysics and Physicobiology".

Ryohei Kondo, Kota Kasahara, Takuya Takahashi
"Information quantity for secondary structure propensities of protein subsequences in the Protein Data Bank"

【Significance】
Although recent great successes of the protein structure predictions, the molecular principles of sequence–structure relationships are not fully understood. In this study, we comprehensively measured the tendency to form a specific structure for subsequences, or N-grams, observed in the Protein Data Bank. Because the current dataset is too sparse to cover the 20N variation of subsequences, we applied information quantity as a measure of the tendency. Higher information quantities indicate the stronger tendency observed in more diverse protein families. As a result, we discovered several thousand subsequences that almost always form a specific secondary structure regardless of its surrounding.

Biophysics Physicobiology, 2022, Volume 19, Article ID: e190002


URL:https://doi.org/10.2142/biophysico.bppb-v19.0002



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