「Biophysics and Physicobiology」に Emi Hibino,Masaru Hoshino による “A novel mode of interaction between intrinsically disordered proteins” を掲載

2020 August 20 BPPB

日本生物物理学会欧文誌[Biophysics and Physicobiology]に以下の論文が公開されました。

Emi Hibino,Masaru Hoshino
"A novel mode of interaction between intrinsically disordered proteins"

The “coupled folding and binding mechanism” has been suggested to be important for intrinsically disordered proteins/regions (IDPs/IDRs) in order to interact with multiple interaction partners in cells. We have studied the structure and interaction of eukaryotic transcription factors Sp1 and TAF4, and found that both of them have several IDRs. One of the IDRs in Sp1 exhibited homo-oligomer formation. The same region was also used for the heteromolecular interaction with TAF4. In both cases, no significant conformational change was detected, suggesting a prominent and novel binding mode for IDPs/IDRs.

Biophysics Physicobiology, Vol.17, pp86-93


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