「Biophysics and Physicobiology」に Yuji Furutani et al." Specific interactions between alkali metal cations and the KcsA channel studied using ATR-FTIR spectroscopy"を掲載
2015 September 16 BPPB
日本生物物理学会欧文誌［Biophysics and Physicobiology］に以下の論文が新規掲載されました。
Yuji Furutani, Hirofumi Shimizu, Yusuke Asai, Shigetoshi Oiki and Hideki Kandori
” Specific interactions between alkali metal cations and the KcsA channel studied using ATR-FTIR spectroscopy”
【Significance】
Vibrational fingerprints of KcsA discriminate its interactions with alkali metal cations.
KcsA, a potassium channel exhibiting high selectivity for potassium ions over sodium ions, achieves selectivity through specific interactions between the cations and the main-chain carbonyl groups within the narrow filter region of the pore. We have applied ion-exchange-induced FTIR difference spectroscopy in attenuated total reflection mode to characterize differences among KcsA’s interactions with various alkali metal cations. Large spectral changes were caused by replacing K＋ with Na＋ or Li＋ but not with Rb＋ or Cs＋. The spectral similarities of the Na＋ and Li＋ conditions suggest that the filter forms a collapsed conformation with each of these ions.
Biophysics and Physicobiology, Vol.12, pp. 37-45
URL: http://doi.org/10.2142/biophysico.12.0_37
