ニュース

「Biophysics and Physicobiology」に Yuhei Tachi, Satoru G. Itoh, Hisashi Okumura による "Molecular dynamics simulations of amyloid-β peptides in heterogeneous environments" を掲載

2022年04月20日 学会誌

日本生物物理学会欧文誌[Biophysics and Physicobiology]に以下の論文が公開されました。

Yuhei Tachi, Satoru G. Itoh, Hisashi Okumura
"Molecular dynamics simulations of amyloid-β peptides in heterogeneous environments"

【Significance】
The aggregates of amyloid-β (Aβ) peptides are considered the cause of Alzheimer’s disease. Aβ aggregation is accelerated at hydrophilic/hydrophobic interfaces such as the air–water interface and the neuronal cell membrane surface. Therefore, understanding the mechanism of the Aβ aggregation in such heterogeneous environments is significant for developing therapeutic agents and preventive drugs. In this review, we survey several studies that have elucidated the mechanism of the Aβ aggregation at the interfaces at the atomic level by molecular dynamics simulations.

Biophysics Physicobiology, 2022, Volume 19, Article ID: e190010



URL:https://doi.org/10.2142/biophysico.bppb-v19.0010



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