ニュース

「Biophysics and Physicobiology」に Ryohei Kondo, Kota Kasahara, Takuya Takahashi による "Information quantity for secondary structure propensities of protein subsequences in the Protein Data Bank" を掲載

2022年02月22日 学会誌

日本生物物理学会欧文誌[Biophysics and Physicobiology]に以下の論文が公開されました。

Ryohei Kondo, Kota Kasahara, Takuya Takahashi
"Information quantity for secondary structure propensities of protein subsequences in the Protein Data Bank"

【Significance】
Although recent great successes of the protein structure predictions, the molecular principles of sequence–structure relationships are not fully understood. In this study, we comprehensively measured the tendency to form a specific structure for subsequences, or N-grams, observed in the Protein Data Bank. Because the current dataset is too sparse to cover the 20N variation of subsequences, we applied information quantity as a measure of the tendency. Higher information quantities indicate the stronger tendency observed in more diverse protein families. As a result, we discovered several thousand subsequences that almost always form a specific secondary structure regardless of its surrounding.

Biophysics Physicobiology, 2022, Volume 19, Article-ID: e190002



URL:https://doi.org/10.2142/biophysico.bppb-v19.0002



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