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「Biophysics and Physicobiology」にDamien Hall “A simple method for modeling amyloid kinetics featuring position biased fiber breakage”を掲載

2020年03月23日 学会から

日本生物物理学会欧文誌[Biophysics and Physicobiology]に以下の論文が公開されました。

Damien Hall “A simple method for modeling amyloid kinetics featuring position biased fiber breakage”

【Significance】
A simple method for modeling amyloid kinetics featuring position biased fiber breakage

A kinetic model of amyloid formation is presented based on two inter-related ordinary differential equations. The model can simply account for different rates of breakage at the fiber ends vs. internal regions. In the former case, breakage releases a monomer unable to maintain its amyloid structure. In the latter case, breakage produces two smaller fibers each able to act as ‘seeds’ able to facilitate amyloid growth. Thus position dependent susceptibility to breakage could determine whether breakage encourages or discourages amyloid growth. These outcomes are crucial when considering the role amyloid growth plays in disease aetiology, such as for Alzheimer’s disease.

公開 5月14日 Biophysics and Physicobiology, Vol.17, pp.30-35
URL:https://doi.org/10.2142/biophysico.BSJ-2020003


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