ニュース

「Biophysics and Physicobiology」にTakuya Yoshizawa et al. “Effect of nuclear import receptors on liquid-liquid phase separation”を掲載

2020年02月28日 学会から

日本生物物理学会欧文誌[Biophysics and Physicobiology]に以下の論文が公開されました。

Takuya Yoshizawa, Hiroyoshi Matsumura “Effect of nuclear import receptors on liquid-liquid phase separation”

【Significance】
Chaperone function of nuclear import receptors

Liquid-liquid phase separation (LLPS) is believed to be a fundamental mechanism during the assembly of membrane-less organelles including RNA granules. Low-complexity (LC) sequences of component proteins have been shown to make a significant contribution to LLPS. The advantage of membrane-less organelles formed by LLPS is flexibility that allows quick assembling and disassembling responding to diverse cellular contexts. Nuclear import receptors may play an important regulatory role in LLPS inhibition. Chaperone function of nuclear import receptors is thought to depend on the tight specific binding of these proteins to the nuclear localization signal and weak transient binding of the LC sequences.

公開 4月4日 Biophysics and Physicobiology, Vol.17, pp.25-29
URL:https://doi.org/10.2142/biophysico.BSJ-2019052 


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