ニュース

「Biophysics and Physicobiology」にShumpei Matsuno et al. “Multidomain protein structure prediction using information about residues interacting on multimeric protein interfaces”を掲載

2020年02月07日 学会から

日本生物物理学会欧文誌[Biophysics and Physicobiology]に以下の論文が新規掲載されました。

Shumpei Matsuno, Masahito Ohue, Yutaka Akiyama “Multidomain protein structure prediction using information about residues interacting on multimeric protein interfaces”

【Significance】
Multidomain protein structure prediction

We have developed a novel multidomain protein structure prediction method named PINE without the need for whole multidomain structure templates. The score for the domain-domain interaction obtained without a structural template of the multidomain protein and score for the three-dimensional structure obtained during protein docking calculation were newly incorporated into the score function. We successfully predicted the structures of 50 of 55 multidomain proteins examined in the test dataset. Interaction residue pair information of the protein-protein complex interface contributes to domain reorganizations even when a structural template for a multidomain protein cannot be obtained.

Biophysics and Physicobiology, Vol.17, 2-13
URL:https://doi.org/10.2142/biophysico.BSJ-2019050


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