ニュース

「Biophysics and Physicobiology」にMarzieh Alishahi et al. “Forced diffusion of water molecules through aquaporin-5 biomembrane; a molecular dynamics study”を掲載

2018年12月28日 学会から

「Biophysics and Physicobiology」にMarzieh Alishahi et al. “Forced diffusion of water molecules through aquaporin-5 biomembrane; a molecular dynamics study”を掲載
日本生物物理学会欧文誌[Biophysics and Physicobiology]に以下の論文が新規掲載されました。

Marzieh Alishahi and Reza Kamali “Forced diffusion of water molecules through aquaporin-5 biomembrane; a molecular dynamics study”

【Significance】
Forced diffusion of water molecules through aquaporin-5 biomembrane; a molecular dynamics study

In this study, Molecular Dynamics method is used to analyze the water permeability and diffusion in Aquaporin-5 (AQP5) structure in a 0.5 microsecond simulation time. For the first time, we have considered the effect of the osmotic water diffusion and the diffusion occurred by pressure gradient on the protein membrane. The water permeability grows monotonically as the applied pressure on the solvent increases. Interestingly, the forced diffusion increases the minimum radius of Selectivity Filter (SF) of region AQP5 up to 20% and consequently the permeability coefficients enhance to a great extent in comparison with osmotic self-diffusion in AQP5 tetramer.


Biophysics and Physicobiology, Vol.15, pp. 255-262
URL: https://doi.org/10.2142/biophysico.15.0_255


前のページに戻る