ニュース

2018年05月28日 掲載 (Published 05/28/2018)


「Biophysics and Physicobiology」にSumita Das et al. “Single-molecular and ensemble-level oscillations of cyanobacterial circadian clock”を掲載

日本生物物理学会欧文誌[Biophysics and Physicobiology]に以下の論文が新規掲載されました。

Sumita Das, Tomoki P. Terada, Masaki Sasai “Single-molecular and ensemble-level oscillations of cyanobacterial circadian clock”

【Significance】
Single-molecular and ensemble-level oscillations of cyanobacterial circadian clock

Cyanobacterial proteins, KaiA, KaiB, and KaiC, can reconstitute a circadian clock when they are incubated with ATP in vitro. In order to understand this prototypical oscillator, we need to analyze both synchronization of a macroscopically large number of oscillating molecules and microscopic reactions in individual molecules. We introduced two theoretical models to unify macroscopic and microscopic viewpoints. Simulation results suggest that ATP hydrolysis is necessary for synchronization and temperature compensation and that ATPase activity is correlated to the oscillation frequency in individual molecules. Thus, ATP hydrolysis stochastically occurring in individual molecules should determine important features of the ensemble-level oscillation.


Biophysics and Physicobiology, pp. 136-150

URL:https://www.jstage.jst.go.jp/article/biophysico/15/0/15_136/_article/