ニュース

2017年09月06日 掲載 (Published 09/06/2017)


「Biophysics and Physicobiology」にAyumi Hashimoto et al. “The change of picrotoxin-induced epileptiform discharges to the beta oscillation by carbachol in rat hippocampal slices ”を掲載

日本生物物理学会欧文誌[Biophysics and Physicobiology]に以下の論文が新規掲載されました。

Ayumi Hashimoto, Toyohiro Sawada, Kiyohisa Natsume “The change of picrotoxin-induced epileptiform discharges to the beta oscillation by carbachol in rat hippocampal slices”

【Significance】
Carbachol changes the evoked patterns of the epileptiform discharges

A cholinergic agent, carbachol, altered the induction patterns of the picrotoxin-induced epileptiform discharges in a concentration-dependent
manner. At the lower concentration it would suppress the synchronous population firing of the pyramidal cells, and in results, carbachol decreased
the amplitude of the discharges and increased the frequency. At the higher concentration, it induced theta or beta oscillations instead of the epileptiform
discharges. Not only hippocampal theta rhythm but also hippocampal beta rhythm would suppress the epileptiform discharges.


Biophysics and Physicobiology, Vol.14, 137-146

URL:https://www.jstage.jst.go.jp/article/biophysico/14/0/14_137/_article