ニュース

2017年08月23日 掲載 (Published 08/23/2017)


「Biophysics and Physicobiology」にHiroaki Machiyama et al. “The use of a genetically encoded molecular crowding sensor in various biological phenomena”を掲載

日本生物物理学会欧文誌[Biophysics and Physicobiology]に以下の論文が新規掲載されました。

Hiroaki Machiyama, Takamitsu J. Morikawa, Kazuko Okamoto, Tomonobu M. Watanabe, Hideaki Fujita “The use of a genetically encoded molecular crowding sensor in various biological phenomena”

【Significance】
Use of crowding sensor

Cells are densely packed with various macro-molecules with water molecules filling the gaps, a phenomenon known as molecular crowding. There has been an increasing interest for molecular crowding as it was shown to influence many biological reactions within cells. In this paper, molecular crowding was monitored during several biological events using a genetically encoded molecular crowding sensor we previously developed. Changes in molecular crowding during stem cell differentiation, cell division, and focal adhesion development and difference in molecular crowding among various filopodia locations were examined. Our results show the usefulness of the genetically encoded molecular crowding sensor for understanding the biological phenomena relating to molecular crowding.


Biophysics and Physicobiology, Vol.14, pp. 119-125

URL:https://www.jstage.jst.go.jp/article/biophysico/14/0/14_119/_article