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「Biophysics and Physicobiology」に Akira R. Kinjo “Liquid-theory analogy of direct-coupling analysis of multiple-sequence alignment and its implications for protein structure prediction”を掲載

2015年12月11日 学会から

日本生物物理学会欧文誌[Biophysics and Physicobiology]に以下の論文が新規掲載されました。

Akira R. Kinjo
“Liquid-theory analogy of direct-coupling analysis of multiple-sequence alignment and its implications for protein structure prediction”

【Significance】
Liquid-theoretical analogy in protein sequence analysis

The direct-coupling analysis (DCA) of protein multiple-sequence alignment (MSA) has been proved to be a good predictor of physical contacts in protein structure. Here, We reformulate the DCA using an analogy from the integral equation theory of liquids. This approach intuitively illustrates that the apparent correlation between two sites in a MSA consists of an infinite series of direct correlations. Based on this result, We discuss the implications of the DCA for protein structure prediction.


Biophysics and Physicobiology, Vol.12, pp. 117-119URL:http://doi.org/10.2142/biophysico.12.0_117


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