ニュース

第2回国際シンポジウム 「Drug Discovery and Design by NMR」

2010年07月09日 会合

主催:よこはまNMR構造生物学研究会

日時:平成22年9月29日(水)~30日(木)  9:30~18:00 (予定)
場所:理化学研究所・横浜研究所交流棟ホール(神奈川県横浜市鶴見区 JR鶴見駅東口より臨港バス「ふれーゆ行」で理研市大大学院前下車)

[プログラム]
【第1日:平成22年9月29日(水)】
9:30- 9:40  Introduction
9:40-10:30 Peter Wright (Scripps, USA)
       Intrinsically disordered proteins: novel targets for drug discovery?
10:30-11:00 Yoshifumi Nishimura (Yokohama City Univ., Japan)
       Disordered proteins and NMR screening of drug candidates
11:00-11:40 Hideo Takahashi (Yokohama City Univ., Japan)
       Molecular Interaction Analyses by NMR for Drug Development
11:40-12:30 Gerhard Wagner (Harvard, USA)
       Inhibitors of protein-protein interactions as anti-tumor and
       immune-suppressive drugs
12:30-13:30 Lunch
13:30-14:00 Takanori Kigawa (Riken, Japan)
       NMR-based Drug Discovery Platform in RIKEN
14:00-14:30 Tai-huang Huang (Academia Sinica, Taiwan)
       Probing the Molecular Interactions in α-ketoacid Dehydrogenase Complexes-A
       Supra-macromolecular Machine and Drug Target for Cancer and Diabetes.
14:30-15:00 Takaaki Miura (Chugai, Japan)
       Enzyme reaction mechanism of human UDPGlcNAc pyrophosphorylase as revealed
       by SPR technology and its significance to fragment screening
15:00-15:20 Intermission
15:20-15:50 Hitoshi Sakashita (Astellas Pharma Inc., Japan)
       Fragment Evolution: Protein Crystallography for Fragment Based Projects in
       Astellas Pharma Inc.
15:50-16:20 Bong-Jin Lee (SNU, Korea)
       Structural insight into Toxin-Antitoxin System of Helicobacter Pylori
16:20-17:10 Wolfgang Jahnke (Novartis, Switzerland)
       NMR in an integrated drug discovery approach
17:30-19:30 Banquet

【第2日:平成22年9月30日(水)】
9:30-10:20 Mitsuhiko Ikura (Univ. Toronto, Canada)
       NMR studies on molecular interactions in cell signaling: weak, intermediate,
       or tight binding
10:20-10:50 Yutaka Ito (Tokyo Metropolitan Univ., Japan)
       In-cell NMR studies of protein structure and dynamics inside living cells
10:50-11:30 Masahiro Shirakawa (Kyoto Univ., Japan)
       Investigation of intracellular space by in-cell NMR and opto-magneto detection
       using nanoparticles
11:30-12:20 Christian Griesinger (MPI, Germany)
       NMR based drug development and mechanism in Neurodegeneration
12:20-13:20 Lunch
13:20-14:10 Thomas L. James (UCSF, USA)
       Targeting Three-Dimensional RNA Structure: Small Molecule Ligand Discovery
       Using Flexible Docking and NMR
14:10-14:50 Bin Xia (Peking Univ., China)
       A Common DNA Binding Mechanism Shared by Nucleoid-Associated Proteins
       H-NS from Gram-Negative Bacteria and Lsr2 from Gram-Positive Bacteria
14:50-15:20 Sam-Yong Park (Yokohama City Univ., Japan)
       The structural basis for an essential subunit interaction in influenza virus RNA
       polymerase
15:20-15:40 Intermission
15:40-16:30 Gregg Siegal (ZoBio,The Netherlands)
       Into the great unknown: Fragment Based Drug Discovery on Membrane Proteins
16:30-17:00 Ichio Shimada (Univ. Tokyo, Japan)
       Functional analyses of membrane proteins by NMR
17:00-17:50 Volker Dotsch (Univ. Frankfurt, Germany)
       Combination of cell-free expression and NMR for the characterization of
       membrane proteins as drug targets
17:50-18:00 Closing

参加費:
正会員無料/非会員5,000円(事前登録要) 詳しくはお問合せ下さい

懇親会:
平成22年9月29日(予定) 会費5,000円(事前登録要) 詳しくはお問合せ下さい

連絡・問い合わせ先:
 〒230-0045横浜市鶴見区末広町1-7-29 
 横浜市立大学大学院生命ナノシステム科学研究科 西村 善文
  TEL:045-508-7530 FAX:045-508-7362 
  E-mail:nisimura@tsurumi.yokohama-cu.ac.jp 又は hiji-555@tsurumi.yokohama-cu.ac.jp
  ※迷惑メール対策の為@は全角で表示しています


URL:http://www.tsurumi.yokohama-cu.ac.jp/ynmr/



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