(Shingo Sotoma, Hirotaka Okita, Shunsuke Chuma, Yoshie Harada, Biophysics and Physicobiology 19, e190034 (2022), DOI: 10.2142/biophysico.bppb-v19.0034)
Physical quantities (i.e. temperature and pH) play an important role in biological activities and thus measuring these parameters at an organelle level inside a cell is essential for a further understanding of life phenomena. Diamond nanoparticles containing nitrogen-vacancy centers have emerged as novel sensors that show great promise for ultrasensitive nanosensing of physical quantities inside a single cell. Here we review the recent advancements in biosensing applications including temperature, angle, and thermal conductivity using the diamond nanoparticles. Understanding cellular activity in terms of physical quantities will create a new wave in life science research.