Title
Structure and Function of Weak Interaction in Metalloproteins - Protein Field and Highly Organized Specific Reaction-

Organizers
Takamitsu Kohzuma (Ibaraki University), Co-organizer: Masaki Unno (Ibaraki University)

Synopsis
The specific structure and function of biological molecules involving protein are accomplished by the accumulation of a number of weak interaction. The correlation between electronic structure and function of biological molecules revealed by the detection of the structure and dynamics of Weak Interaction is expected to elucidate the Protein Folding Principal, Function, and Molecular Mechanisms of Protein. Such knowledge of the Protein Weak Interaction is applicable for the design of new protein as the nano scaled Green materials. Protein also gives a very specific reaction field, "Protein Field". Very recently, "2nd coordination sphere" effect on the protein structure and function has been studied. The 2nd coordination sphere is defined as the remote structure, which is far from the active site of Metalloproteins. The unique chemical features like ligand to metal charge transfer (CT)and heme moieties of metalloproteins are very sensitive to the small, but significant structural rearrangements. Such unique properties allows us to understand the information transfer from the "2nd coordination sphere" to the active site in metalloproteins through many varieties of modern techniques like precise crystallography with atomic resolution, spectroscopy, and quantum chemical calculation.
The detection of weak interaction, the correlation between the structure construction principal and molecular functions in metalloproteins and the “Protein Field” providing specific reaction will be discussed in this sympsium.


Speakers
・ Tomoko Miyazaki, Saburo Neya, Junji Teraoka (Osaka City University): A Breathing Raman Band Reveals Heme-Globin Interaction
・ Takashi Ogura, Sachiko Yanagisawa, Hiroshi Sugimoto and Yoshitsugu Shiro (University of Hyogo): Interaction between Substrate and Dioxygen in the Enzyme/Substrate/DioxygenTernary Complex of Indoleamine Dioxygenase as Probed with Resonance Raman Spectroscopy
・ Takeshi Uchida (Hokkaido University): Heme transfer mechanism of heme chaperone protein
・ Masaki Unno (Ibaraki University): Understanding of Nitric Oxide-Binding Mechanism of Cytochrome c' Based on Atomic Resolution Structures
・ Seiji Mori (Ibaraki University): Theoretical analysis for structures and reaction mechanisms of atypical cytochrome P450
・ Junko Yano (Lawrence Berkeley National Laboratory, Berkeley, U.S.A.): Radiation Damage in Redox Proteins 
・ Martin Stillman (The University of Western Ontario): Metallation status and metalloprotein conformations: Tracking subtle changes using time-resolved ESI-mass spectrometry





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