Title
Recent Advances in Structural Analyses of Funcitonal Mechanisms Based on Dynamics of Biological Reactions
Organizers
Masaru Tateno (Tsukuba University), Takashi Hayashi (Osaka University)
Synopsis
To understand functional reaction mechanisms of biological macromolecules involving proteins and nucleic acids, the dynamical properties as well as high resolution three-dimensional (3D) structures of the molecules are to be elucidated. In this symposium, we focus on structural and computational analyses relevant to reactions such as enzymatic catalysis, proton/electron transfer, etc. In particular, to understand detailed dynamical properties of the molecules, we would like to emphasize the importance and need to combine experimental and theoretical methodologies, which are complementary. From such a point of view, the following systems will be discussed in the symposium:
1) Recent advances on reaction mechanisms of Cytochrome P-450cam and Cytochrome c oxidase involving new aspects concerning binding mechanisms of ligand
2) Reaction mechanisms of RNA and RNA-binding proteins relevant to translational systems, and the evolution of life based on such catalytic mechanisms
To resolve these issues, dynamics of electronic structures as well as 3D structures of the molecules are required to be elucidated. For the purpose, what should we do in the next phase of our biophysics ? It is the most crucial subject of this symposium.
Speakers
・Takashi Hayashi (Osaka University)
・ Masaru Tateno (Tsukuba University): Biocatalytic mechanisms based on dynamics of elctronic structures
・ Kazumasa Muramoto (Universiyty of Hyogo )
・ Osamu Nureki (The Universiyty of Tokyo )
・ Hiroaki Suga (The Universiyty of Tokyo )
・ Martin Field (Structural Biology Center (Grenoble, France)): Mechanisms of enzymatic reaction using molecular dynamics and hybrid qunatum mechanics potential calculations (tentative)
シンポジウムのリストへ戻る
Recent Advances in Structural Analyses of Funcitonal Mechanisms Based on Dynamics of Biological Reactions
Organizers
Masaru Tateno (Tsukuba University), Takashi Hayashi (Osaka University)
Synopsis
To understand functional reaction mechanisms of biological macromolecules involving proteins and nucleic acids, the dynamical properties as well as high resolution three-dimensional (3D) structures of the molecules are to be elucidated. In this symposium, we focus on structural and computational analyses relevant to reactions such as enzymatic catalysis, proton/electron transfer, etc. In particular, to understand detailed dynamical properties of the molecules, we would like to emphasize the importance and need to combine experimental and theoretical methodologies, which are complementary. From such a point of view, the following systems will be discussed in the symposium:
1) Recent advances on reaction mechanisms of Cytochrome P-450cam and Cytochrome c oxidase involving new aspects concerning binding mechanisms of ligand
2) Reaction mechanisms of RNA and RNA-binding proteins relevant to translational systems, and the evolution of life based on such catalytic mechanisms
To resolve these issues, dynamics of electronic structures as well as 3D structures of the molecules are required to be elucidated. For the purpose, what should we do in the next phase of our biophysics ? It is the most crucial subject of this symposium.
Speakers
・Takashi Hayashi (Osaka University)
・ Masaru Tateno (Tsukuba University): Biocatalytic mechanisms based on dynamics of elctronic structures
・ Kazumasa Muramoto (Universiyty of Hyogo )
・ Osamu Nureki (The Universiyty of Tokyo )
・ Hiroaki Suga (The Universiyty of Tokyo )
・ Martin Field (Structural Biology Center (Grenoble, France)): Mechanisms of enzymatic reaction using molecular dynamics and hybrid qunatum mechanics potential calculations (tentative)
シンポジウムのリストへ戻る