Title
High-Energy Paradigm of Protein Structures

Organizers
Masayuki Oda (Kyoto Prefectural University), Ryo Kitahara (Ritsumeikan University)

Synopsis
Our concept of protein structure is now facing a challenge. Although we have some 50,000 structures enrolled in PDB, our understanding of the dynamic aspects of life including various physiological processes, evolution, adaptation, disease and drug-action remains illusive. In our view, this is partly because our knowledge on protein structures has been restricted largely to those basic folded structures in crystals and in solution. To advance out understanding of the life phenomena on molecular basis, we need to expand our concept of protein structures from the basic folded paradigm into the “high-energy paradigm” where versatile and subtle conformational variations are present. This symposium represents our effort to promote our understanding of life in a simpler and unified way by invoking the “high-energy paradigm” of protein structures as the major functional space of proteins.

Speakers
・Kazuyuki Akasaka (Kinki University): Invitation to the High-Energy Paradigm of Protein Structures
・ Kunitsugu Soda (RIKEN): Structural-Fluctuation Dynamics and High-Energy Structure of Protein
・ Hua Li (RIKEN): Low-Lying Excited States of Proteins Revealed by Variable-Pressure NMR Spectroscopy
・ Akihiro Maeno (Kinki University): Cavity Hydration: A Gate Way to the High-Energy Paradigm ?
・Ryo Kitahara (Ritsumeikan University): The Functional Importance of Locally Disordered Structures of Proteins
・Hideki Tachibana (Kinki University): Volumetric Properties of Amyloid Fibrillation Starting from Unfolded High-Energy Protein Structures
・Ryuichiro Atarashi (Nagasaki University): High-Energy Conformers of Prion Proteins: A Key to the Abnormal Fibril Formation







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