Title
Fluctuation and Function of Biomolecules

Organizers
Ryota Iino (Osaka University), Kiichiro Totani (Seikei University)

Synopsis
The structures of biomolecules such as proteins, DNA and lipid membranes are not static but dynamically fluctuating under the physiological condition. The fluctuations are known to induce various effects on the individual biomolecules. Recently, although the importance of fluctuation is widely accepted, the variety of these effects hampered to understand molecular basis on how fluctuation correlates with biological function. In this symposium, researchers who are trying to understand this issue using various approaches such as bioorganic chemistry, spectroscopy, molecular simulation, live-cell imaging, and single-molecule method will get together. The subjects include fluctuation of proteins (i.e. motor protein, glycoprotein processing enzyme, transcription factor), DNA (i.e. DNA-water and DNA-protein interaction) and lipid membranes (i.e. domain formation of lipid bilayer, two-dimensional Brownian motion of lipid in bilayer). Current status of our understandings and future perspectives towards fluctuation of biomolecules will be argued comprehensively and thoroughly.

Speakers
・Ryota Iino (Osaka University): Fluctuation and function of a rotary motor protein
・Kiichiro Totani (Seikei University): Enzymatic property under intra- and extracellular specific environments
・Kenji Sugase (Suntory Institute for Bioorganic Research): Fluctuation and function of nuclear proteins
・Yoshiteru Yonetani (Japan Atomic Energy Agency): Dynamics of water and proteins interacting with DNA
・Hiroaki Yokota (Kyoto University): Single-molecule imaging of DNA-protein interactions
・Kazuya Kabayama (Tokai University): Glycolipid-enriched microdomain control lateral diffusion of membrane receptors
・Ryugo Tero (Institute for Molecular Science): Micro-structure formation and its effect on molecular diffusion in lipid bilayer membranes





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