Title
Biophysics of Multicellular Systems

Organizers
Satoshi Sawai (The University of Tokyo), Kunihiko Kaneko (The University of Tokyo)

Synopsis
Understanding actual dynamics at the multicellular level has often been limited experimentally by difficulties in breaking processes into smaller parts. Recent advances in quantitative measurements of cellular and subcellular events are now making it possible for one to reconstruct the behavior of developing tissues based on well-defined intra- and intercellular properties. In this symposium, we highlight studies that are providing new insights into the dynamical organization of cellular communities. Here, we see that by combining methods in live-cell imaging, quantitative/computational analysis and mathematical modeling, concepts that have so far remained purely theoretical in the field of nonlinear dynamics and complex physical systems are now gaining grounds in biology. These are features inherent in high-dimensional nonlinear systems such as bifurcation and phase transition-like behaviors, complex oscillations, noise-induced order, multi-stability and selection of attractors. From this series of talks, we shall see that knowledge of these properties when fully implemented in their experimental designs could be a huge resource for those analyzing multicellular systems quantitatively.

Speakers
・ Satoshi Sawai (The University of Tokyo): How collective behavior begins in social amobae communities
・ Takao Suzuki (RIKEN): Quantitative analyses and adaptive design of butterfly and moth wing patterns towards a dead leaf resemblance
・ Kaoru Sugimura (RIKEN): Pattern of the stress field and dynamics of morphogenesis
・ Chikara Furusawa (Osaka University): A dynamic model of cell differentiation: Toward understanding of stem cell systems
・ Toshihiko Fujimori (NIBB): Cellular behaviors in early mammalian embryonic development
・ Kunihiko Kaneko (The University of Tokyo): Future Prospect






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