Title
Actin as a Cytomotive Filament
Organizers
Naoki Watanabe (Tohoku University), Yuichiro Maeda (Nagoya University)
Synopsis
Actin filaments are highly dynamic in the cell, continuously undergoing polymerization and disassembly. Actin dynamics not only provides a classical cell motile force generator but also regulates various higher functions. For example in neuron, the formation and the loss of F-actin are presumably linked to the formation and the loss of memory through morphological changes in the dendritic spine. The role of actin dynamics in cancer cell invasion is under vigorous investigation. In plants, the actin cytoskeleton plays an essential role in chloroplast movement and pollen tube growth. On the other hand, ultra fine F-actin structures provide new insights into the dynamics of actin molecules such as conformational modulation of actin filaments on which myosins ‘walk’. Single-molecule observation of actin regulators such as processively-actin polymerizing formin homology proteins has shown that F-actin turnover is coupled to the intracellular gradient of actin regulators and cell signaling intermediates. In this symposium, we will discuss the functions of actin dynamics with a wide range of life science and basic medicine researchers. Dynamics of actin molecules should exert their effects through basically conserved molecular and physiological mechanisms between distinct cells and body functions. Therefore this symposium aims to exchange the recent progress obtained using diverse cell systems.
Speakers
・ Yuichiro Maeda (Nagoya University): Structural basis of cytomotive activity of the actin filament
・ Tai Kiuchi (King's College London): Critical role of actin monomer concentration in stimulus-induced actin assembly and cell extension
・ Yasunori Hayashi (RIKEN): Dynamics of actin during hippocampal synaptic plasticit
・ Shiro Suetsugu (The University of Tokyo): Dynamics of actin filaments for subcellular membrane structures
・ Jiro Usukura (Nagoya University): Dynamics of actin filaments for subcellular membrane structures
・ Naoki Watanabe (Tohoku University): Mechanosensitive actin nucleation and filament regeneration
シンポジウムのリストへ戻る
Actin as a Cytomotive Filament
Organizers
Naoki Watanabe (Tohoku University), Yuichiro Maeda (Nagoya University)
Synopsis
Actin filaments are highly dynamic in the cell, continuously undergoing polymerization and disassembly. Actin dynamics not only provides a classical cell motile force generator but also regulates various higher functions. For example in neuron, the formation and the loss of F-actin are presumably linked to the formation and the loss of memory through morphological changes in the dendritic spine. The role of actin dynamics in cancer cell invasion is under vigorous investigation. In plants, the actin cytoskeleton plays an essential role in chloroplast movement and pollen tube growth. On the other hand, ultra fine F-actin structures provide new insights into the dynamics of actin molecules such as conformational modulation of actin filaments on which myosins ‘walk’. Single-molecule observation of actin regulators such as processively-actin polymerizing formin homology proteins has shown that F-actin turnover is coupled to the intracellular gradient of actin regulators and cell signaling intermediates. In this symposium, we will discuss the functions of actin dynamics with a wide range of life science and basic medicine researchers. Dynamics of actin molecules should exert their effects through basically conserved molecular and physiological mechanisms between distinct cells and body functions. Therefore this symposium aims to exchange the recent progress obtained using diverse cell systems.
Speakers
・ Yuichiro Maeda (Nagoya University): Structural basis of cytomotive activity of the actin filament
・ Tai Kiuchi (King's College London): Critical role of actin monomer concentration in stimulus-induced actin assembly and cell extension
・ Yasunori Hayashi (RIKEN): Dynamics of actin during hippocampal synaptic plasticit
・ Shiro Suetsugu (The University of Tokyo): Dynamics of actin filaments for subcellular membrane structures
・ Jiro Usukura (Nagoya University): Dynamics of actin filaments for subcellular membrane structures
・ Naoki Watanabe (Tohoku University): Mechanosensitive actin nucleation and filament regeneration
シンポジウムのリストへ戻る